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High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice.
Serrano J, Smith KR, Crouch AL, Sharma V, Yi F, Vargova V, LaMoia TE, Dupont LM, Serna V, Tang F, Gomes-Dias L, Blakeslee JJ, Hatzakis E, Peterson SN, Anderson M, Pratley RE, Kyriazis GA. Serrano J, et al. Among authors: lamoia te. Microbiome. 2021 Jan 12;9(1):11. doi: 10.1186/s40168-020-00976-w. Microbiome. 2021. PMID: 33431052 Free PMC article. Clinical Trial.
T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways.
Smith K, Karimian Azari E, LaMoia TE, Hussain T, Vargova V, Karolyi K, Veldhuis PP, Arnoletti JP, de la Fuente SG, Pratley RE, Osborne TF, Kyriazis GA. Smith K, et al. Among authors: lamoia te. Mol Metab. 2018 Nov;17:98-111. doi: 10.1016/j.molmet.2018.08.009. Epub 2018 Aug 27. Mol Metab. 2018. PMID: 30201274 Free PMC article.